The concept of closed nuclear fuel cycle seems to be the most promising options for the efficient usage of the nuclear energy resources.However, it can be implemented only in fast breeder reactors of the IVth generation, which are characterized by the fast neutron spectrum.The lead-cooled fast reactor (LFR) was defined and studied on the level of t
Based on previous large-scale in silico screening several Packing Cubes factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro.In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic effect on patients with COVID-19 disease.In this study we examined the binding of the Apix
Abstract Background and objectives Nirmatrelvir/ritonavir was administered orally to manage mild to moderate symptoms of COVID-19 in adult patients.The objectives of this study were to (i) evaluate the cost-effectiveness of prescribing nirmatrelvir/ritonavir within 5 days of a COVID-19 illness in order to avert hospitalization within Shakes a 30-da
Enhanced vascular permeability in the lungs can lead to pulmonary edema, impaired gas exchange, and ultimately respiratory failure.While oxygen delivery, mechanical ventilation, and pressure-reducing medications help alleviate these symptoms, they do not treat the underlying disease.Mechanical activation of transient receptor potential vanilloid 4